Publications

1. D.R. Mould and Bruce Green "Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies: concepts and lessons for drug development" Biodrugs (2010) 24(1):23-39

2. DR Mould, K Sweeney, SB Duffull, E Neylon, P Hamlin, S Horwitz, F Sirotnak, M Fleisher, ME Saunders and OA O’Connor "A Population Pharmacokinetic and Pharmacodynamic Evaluation of Pralatrexate in Patients With Relapsed or Refractory Non‑Hodgkin's or Hodgkin's Lymphoma" Clin. Pharmacol. Ther. (2009)

3. Elizabeth Y. Shang, Megan A. Gibbs, Jaren W. Landen, Michael Krams, Tanya Russell, Nicholas G. Denman, Diane R. Mould "Evaluation of Structural Models to Describe the Effect of Placebo upon the Time Course of Major Depressive Disorder" J Pharmacokinet Pharmacodyn (2009) 36:63-80

4. Feillet F, Clarke L, Meli C, Lipson M, Morris AA, Harmatz P, Mould DR, Green B, Dorenbaum A, Giovannini M, Foehr E; Sapropterin Research Group "Pharmacokinetics of Sapropterin in Patients with Phenylketonuria" Clin Pharmacokinet. 47 (12):817-25 2008

5. D.R. Mould, K. Sweeney, S. Duffull, E. Neylon, and O.A. O’Connor "A Population Pharmacokinetic And Pharmacodynamic Evaluation of Pralatrexate" J Clin Oncol Submitted October 2008

6. WB. Smith, TC. Marbury, SF. Komjathy, M. Sumeray, DR Mould. "Pharmacokinetics and Pharmacodynamics of Clevidipine after Prolonged Continuous Infusion in Patients with Essential Hypertension." Submitted 2008

7. O.A. O’Connor, P. Hamlin, C. Moskowitz, C. Portlock, D. Sarasohn; E. Neylon, J. Mastrella, R. Hamelers, B. Mac-Gregor-Cortelli, M. Paterson, A. D. Zelenetz, F. Sirotnak, M. Fleischer. D.R. Mould, M. Saunders, P. Cagnoni, S. Horwitz "A Phase ‘2-1-2’ Study of Two Different Doses and Schedules of Pralatrexate, a High Affinity Substrate for the Reduced Folate Carrier (RFC-1), in Patients with Relapsed or Refractory Lymphoma Reveals Marked Activity in T-cell Malignancies" J Clin Oncol Submitted October 2008

8. C. Cronenberger, D.R. Mould, H-J. Roethig, and M. Sarkar "Population Pharmacokinetic Analysis of Carboxyhemoglobin Levels in Adult cigarette smokers" British J. Clin. Pharmacol. 65 (1):30-39 2008

9. A. Roy, R. Raymond, D.R. Mould, X-F. Wang, L. Tay and M. Pfister "Modeling and Simulation of Abatacept Exposure and Interleukin-6 Response in Support of Recommended Doses for Rheumatoid Arthritis" J Clin Pharmacol 47: 1408-1420 2007

10. O.A. O’Connor, P. Hamlin, C. Portlock, C. Moskowitz, A. Noy, D. Straus, B. MacGregor-Cortelli, E. Neylon, J. Pappanicolu, O. Dumetrescu, D.R. Mould, M. Fleischer, A.D. Zelenetz, S. Horwitz "Pralatrexate, A Novel Class of Antifolate with High Affinity for the Reduced Folate Carrier-Type 1, Produces Marked Complete and Durable Remissions in a Diversity of Chemotherapy Refractory Cases of T-cell Lymphoma" British J. Haematol. 139(3):425-8 2007

11. D.R. Mould, A. Baumann, J. Kuhlmann, M.J. Keating, S. Weitman, P. Hillmen, L.R. Brettman, S. Reif, and P.L. Bonate "Population Pharmacokinetics-Pharmacodynamics of Alemtuzumab (Campath®) in Patients with Chronic Lymphocytic Leukemia" British J. Clin. Pharmacol. 64(3):278-291 2007

12. D.R. Mould, N.G. Denman, S. Duffull "Using Disease Progression Models as a Tool to Detect Drug Effect" Clin. Pharmacol. Ther. 82(1):81-86 2007

13. D.R. Mould and K.D Sweeney "A Review of the Pharmacokinetics and Pharmacodynamics of Monoclonal Antibodies – Mechanistic Modeling Applied to Drug Development" Current Opinion in Drug Discov. and Devel. 2007 10(1): 84-96

14. S.J. Tannenbaum, N.H.G. Holford, H. Lee, C.C. Peck, and D.R. Mould "A Method for Simulation of Correlated Continuous and Categorical Variables using a Single Multivariate Distribution" J. Pharmacokin. Pharmacodyn. 2006 33(6):773-94

15. D.R Mould, G.F. Fleming, K.M. Darcy, and D. Spriggs "Population Analysis of a 24-hour Paclitaxel Infusion in Advanced Endometrial Cancer: A Gynecologic Oncology Group Study" British J. Clin. Pharmacol. 2006 62(1):56-70

16. J Martin and D.R. Mould "Clinical Pharmacology: Drug Action in Progressing Disease" Eur J Hospital Pharm. Practice 2006 12(3):38-39

17. D.R. Mould, K. Nieforth, X. Zhang, M. Salgo, I. H. Patel "Population Pharmacokinetics of Enfuvirtide in Patients with Human Immunodeficiency Virus" Clin. Pharmacol. Ther. 2005 Jun;77(6):515-28

18. D.R. Mould, N.H.G. Holford, J.H.M. Schellens, J.H. Beijnen, P.R. Hutson, H. Rosing, W.W. ten Bokkel Huinink, EK Rowinsky, J.H. Schiller, M Russo, and G Dane MBChB "Pooled Pharmacokinetic and Adverse Event Analysis of Topotecan in Patients with Solid Tumors" Clin. Pharmacol. Ther. 2002 May;71(5):334-48

19. D.R. Mould, J.B. Aluri, M.C. Chapelsky, J.G. Granett, R. Samuels "A Population Pharmacokinetic Pharmacodynamic and Logistic Regression Analysis of Lotrafiban" Clin Pharmacol Ther 2001 69(4):209-222

20. S. Aktar, R.A. Beckman, D.R. Mould, S.Z. Fields, J. Wright "A Phase I Open Label Two Period Cross Over Study to Compare the Bioavailablility of a Single Dose of Oral Topotecan in the Presence or Absence or Ranitidine." Cancer Chemother Pharmacol. 2000;46(3):204-10

21. D.R. Mould, C.B. Davis, E.A. Minthorn, D.C. Kwok, M.J. Eliott, M.E. Luggen, and M.C. Totoritis "Population Pharmacokinetic/Pharmacodynamic Analysis of the Effects of Clenoliximab, a PRIMATIZED™ anti-CD4 monoclonal antibody, on T lymphocytes, following single doses to patients with active rheumatoid arthritis." Clin. Pharmacol. Ther., 1999 Sep;66(3):246-57

22. F. Vincenti, M. Lantz, J. Birnbaum, M. Garovoy, D. Mould, J. Hakimi K. Nieforth and S. Light "A Phase I Trial of Humanized Anti Interleukin-2 Receptor Antibody in Renal Transplantation" Transplantation 63(1) 1-5:1997

23. K.A. Nieforth, R. Nadeau, I.H. Patel and D.R. Mould "Use of an Indirect Pharmacodynamic Stimulation Model to Compare In Vitro Activity of Interferon α-2a and a Poly(Ethylene Glycol) Modified Derivative in Healthy Subjects" Clin. Pharmacol. Ther., 59(6):636-646 1996

24. B. Fayer, P. Soni, M.H. Binger, D.R. Mould and H. Satoh "Determination of Humanized Anti-TAC in Human Serum by a Sandwich Enzyme Linked Immunosorbent Assay" J. Immunological Methods 186:47-54 1995

25. D.R. Mould, T.M. DeFeo, S.B. Reele G. Milla, R. Limjuco, T. Crews, N. Choma, and I.H. Patel "Simultaneous Modeling of the Pharmacokinetics and Pharmacodynamics of Midazolam and Diazepam" Clin. Pharmacol. Ther., 58(1):35-43 1995

26. C. Anasetti, J. Hansen, T. Waldmann, F. Appelbaum, J. Davis, J. Deeg, K. Dooney, P. Martin, R. Nash, R. Storb, K. Sullivan, R. Witherspoon, M. Binger, R. Chizzonite, J. Hakimi, D. Mould, H. Satoh, S. Light "Treatment of Acute GVHD with Humanized Anti TAC: An Antibody That Binds to the Interleukin-2 Receptor" Blood 84(4):1320-1327 1994.

27. C. Anasetti, M.-H. Binger, T. Waldmann, D. Mould, H. Satoh, F.R. Appelbaum, H.J. Deeg, K. Doney, P.J. Martin, R. Nash, R. Storb, K.M. Sullivan, R.P. Witherspoon and J.A. Hansen "Treatment of Acute Graft-Versus-Host Disease with a Humanized Monoclonal Antibody Specific for the IL-2 Receptor" Blood Supplement 80(10):373-374A 1992.

28. S.D. Black and D.R. Mould "Calculation and Evaluation of Side-Chain Hydrophobicity for Physiological Amino Acids and Modified Derivatives" Analytical Biochem. 193:72-82 1991.

29. D.R. Mould, J.W. Duane and E.L. Gross "Solid Modeling Used in Protein Design and Analysis" ASEE Proc. Ann. Conference 2(1):1049-1053 1986.